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Sibutramine CAS Registry Number: 106650-56-0 西布曲明

CAS Name: 1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclobutanemethanamine
Additional Names: N-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl-N,N-dimethylamine
Percent Composition: C 72.96%, H 9.36%, Cl 12.67%, N 5.01%

📌 参考资料/链接：
Literature References: Serotonin and noradrenaline reuptake inhibitor (SNRI); decreases calorie intake and increases energy expenditure. Prepn: J. E. Jeffery et al., DE 3212682; idem, US 4929629 (1982, 1990 both to Boots). Clinical trial in obesity: C. Hanotin et al., Int. J. Obes. 22, 32 (1998). Review of pharmacology and mechanism of action: D. J. Heal et al., ibid., Suppl. 1, S18-S28.

📄 详细内容

Derivative Type: Hydrochloride monohydrate
CAS Registry Number: 125494-59-9Trademarks: Reductil (Knoll); Meridia (Knoll)
Percent Composition: C 61.07%, H 8.74%, Cl 21.21%, N 4.19%, O 4.79%
Properties: Crystals from water, mp 193-195.5°. Partition coefficient (octanol/water): 30.9 (pH 5.0). Soly in water: 2.9 mg/ml at pH 5.2.
Melting point: mp 193-195.5°
Log P: Partition coefficient (octanol/water): 30.9 (pH 5.0)
NOTE: This is a controlled substance (stimulant):
21 CFR, 1308.14.
Therap-Cat: Antiobesity agent.
Keywords: Anorexic; Antiobesity Agent; Serotonin Noradrenaline Reuptake Inhibitor (SNRI).
产品链接: 106650-56-0››

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