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Cefotiam CAS Registry Number: 61622-34-2 头孢替安

CAS Name: (6R,7R)-7-[[(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Names: 7b-[2-(aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylic acidPercent Composition: C 41.13%, H 4.41%, N 23.98%, O 12.18%, S 18.30%

📌 参考资料/链接：
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: S. Terao et al., DE 2458695; M. Numata et al., US 4080498 (1975, 1978 both to Takeda); eidem, J. Antibiot. 31, 1262 (1978). Prepn of the crystalline dihydrochloride: K. Naito et al., DE 2738711; eidem, US 4146710 (1978, 1979 both to Takeda). Pharmacodynamics: K. Tsuchiya et al., ibid., 1272. Antibacterial spectrum: eidem, Antimicrob. Agents Chemother. 14, 557 (1978). Clinical trial in respiratory infections: H. M. Beumer et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 23, 105 (1985).

📄 详细内容

Derivative Type: Dihydrochloride
CAS Registry Number: 66309-69-1Trademarks: Halospor (Novartis); Pansporin (Takeda); Pansporine (Cassenne-Takeda); Spizef (Grñenthal); Sporidyn (Cyanamid)
Percent Composition: C 36.12%, H 4.21%, N 21.06%, O 10.69%, S 16.07%, Cl 11.85%
Properties: White to light yellow crystals. Sol in methanol. Slightly sol in ethanol.
Derivative Type: 1-(Cyclohexyloxycarbonyloxy)ethyl ester dihydrochloride
CAS Registry Number: 95789-30-3
Additional Names: Cefotiam hexetil hydrochlorideTrademarks: Pansporin T (Takeda); Taketiam (Takeda); Texodil (Cassenne)
Percent Composition: C 42.18%, H 5.11%, N 16.40%, O 14.57%, S 12.51%, Cl 9.22%
Literature References: Prepn: T. Nishimura et al.,
EP
128029; eidem,
US
5120841 (1984, 1992 both to Takeda); eidem et al., J. Antibiot.
40, 81 (1987). Acute toxicity: S. Chiba et al., Oyo Yakuri
35, 179 (1988), C.A.
109, 31615c (1988). Clinical trial: H. Maier et al. Arzneim.-Forsch.
42, 980 (1992).
Properties: Colorless powder. Soly in water at pH 4.5: 1 mg/ml. LD50 in male, female mice, male, female rats (mg/kg): 1290, 1150, 1470, 1620 i.p.; 2000 s.c.; 5000 orally (Chiba).
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 1290, 1150, 1470, 1620 i.p.; 2000 s.c.; 5000 orally (Chiba)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.
产品链接: 61622-34-2››

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