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Dicloxacillin CAS Registry Number: 3116-76-5 双氯西林

CAS Name: (2S,5R,6R)-6-[[[3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Additional Names: 6-[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarboxamido]penicillanic acid; 3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolylpenicillinTrademarks: Maclicine (Christiaens)
Percent Composition: C 48.52%, H 3.64%, Cl 15.08%, N 8.93%, O 17.01%, S 6.82%

📌 参考资料/链接：
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn: J. H. C. Naylor, GB 978299; eidem, US 3239507 (1965, 1969 to Beecham). Toxicity data: C. Gloxhuber et al., Arzneim.-Forsch. 15, 322 (1965). Series of articles on chemistry, pharmacology and toxicology: ibid. 322-348; Matsuzaki, Jpn. J. Antibiot. 21, 274, 284 (1968), C.A. 70, 95267z, 95265x (1969).

📄 详细内容

Derivative Type: Sodium salt monohydrate
CAS Registry Number: 13412-64-1
Additional Names: Sodium dicloxacillin monohydrateTrademarks: Brispen; Dichlor-Stapenor (Bayer); Diclocil (BMS); Dycill (SKB); Dynapen (Apothecon); Noxaben (Unifa); Pathocil (Wyeth); Pen-Sint (Cophar); Syntarpen (Polfa); Veracillin (Ayerst)
Percent Composition: C 44.72%, H 3.56%, Cl 13.89%, N 8.23%, Na 4.50%, O 18.81%, S 6.28%
Properties: Crystals, dec 222-225°. [a]D20 +127.2° (water). Sol in water, methanol; less sol in butanol; slightly sol in acetone and the usual organic solvents. LD50 in mice (g/kg): 0.9 i.v.; in rats (g/kg): 0.63 i.p.; 5 orally (Gloxhuber).
Optical Rotation: [a]D20 +127.2° (water)
Toxicity data: LD50 in mice (g/kg): 0.9 i.v.; in rats (g/kg): 0.63 i.p.; 5 orally (Gloxhuber)
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Penicillins.
产品链接: 3116-76-5››

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