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Sabcomeline CAS Registry Number: 159912-53-5 沙可美林

CAS Name: R-(Z)-a-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrilePercent Composition: C 62.15%, H 7.82%, N 21.74%, O 8.28%

📌 参考资料/链接：
Literature References: Selective muscarinic M1-receptor partial agonist. Prepn: B. S. Orlek et al., EP 392803; eidem, US 5278170; (1990, 1994 both to Beecham); S. M. Bromidge et al., J. Med. Chem. 40, 4265 (1997). Pharmacology: J. M. Loudon et al., J. Pharmacol. Exp. Ther. 283, 1059 (1997). Cognition improvement in rats: H. Hodges et al., Behav. Brain Res. 99, 81 (1999).

📄 详细内容

Properties: White crystals from methanol-acetone, mp 154-156°. [a]D20 +14.4° (c = 0.424 in EtOH).
Melting point: mp 154-156°
Optical Rotation: [a]D20 +14.4° (c = 0.424 in EtOH)
Derivative Type: Hydrochloride
CAS Registry Number: 159912-58-0
Trademarks: Memric (GSK)
Percent Composition: C 52.29%, H 7.02%, N 18.29%, O 6.97%, Cl 15.43%
Properties: mp 218-219°. [a]D20 +25.3° (c = 1.00 in EtOH).
Melting point: mp 218-219°
Optical Rotation: [a]D20 +25.3° (c = 1.00 in EtOH)
Therap-Cat: Nootropic
Keywords: Nootropic.
产品链接: 159912-53-5››

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