Properties: Yellow solid. Weakly acidic. [a]D22 -60° (c = 1 in methanol). uv max (methanol/water): 233, 276, 286, 327 nm. Sol in chloroform, methyl isobutyl ketone, butyl acetate, ethyl acetate, acetone, methanol, alkaline soln. Slightly sol in CCl4, benzene. Insol in diethyl ether, petr ether, water, acid soln. Stable for 4 hrs in 50% aq methanol at pH 3-12. The solid antibiotic stored at 25° and 37° and low relative humidity shows no activity loss for 5 mos. Stable for 3 mos at 25°, 100% relative humidity; for 2 mos at 37°, 100% relative humidity. LD50 i.p. in mice: 1000 mg/kg (DE 2140674).
Optical Rotation: [a]D22 -60° (c = 1 in methanol)
Absorption maximum: uv max (methanol/water): 233, 276, 286, 327 nm
Toxicity data: LD50 i.p. in mice: 1000 mg/kg (DE 2140674)
Derivative Type: 1-Methyl deriv see Aurodox
Derivative Type: 5,6-Dihydromocimycin
Percent Composition: C 64.64%, H 7.82%, N 3.51%, O 24.03%
Literature References: Isoln from S. ramocissimus and properties: H. Jongsma et al.,
DE
2658977 (1977 to Gist-Brocades), C.A.
87, 135078y (1977); see also C. Vos et al.,
US
4062948 (1977 to Gist-Brocades).
Properties: Pale yellow solid, dec begins at 123°. [a]D20 -85° (1% methanolic soln). uv max (methanol/water): 233.5, 267, 291, 333 nm (e 63000, 23000, 19000, 18000). Solubility similar to mocimycin in most solvents.
Optical Rotation: [a]D20 -85° (1% methanolic soln)
Absorption maximum: uv max (methanol/water): 233.5, 267, 291, 333 nm (e 63000, 23000, 19000, 18000)
Use: Animal growth promotant.
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