Aplasmomycin CAS Registry Number: 61230-25-9 硼酸盐(1-),[(1R,2R,5S,6R,8S,9E,12R,14S,17R,18R,19R,22S,23R,25S,26E,29R,31S,34R)-1,2,18,19-四(羟基-kO)-12,29-二羟基-6,13,13,17,23,30,30,34-辛甲基-4,7,21,24,35,37-六氧喷环[29.3.1.15,8.114,18.122,25]octa三十-9,26-二烯-3,20-dionato(4-)]-,钠(1:1),(T-4)-

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Literature References: Antibiotic produced by Streptomyces griseus strain SS-20, obtained from shallow sea mud: Y. Okami et al., J. Antibiot. 29, 1019 (1976); eidem, JP Kokai 77 108901 (1977 to Microbiochem. Res. Found.), C.A. 88, 35843 (1978). It inhibits the growth of gram-positive bacteria in vitro and is active vs Plasmodium berghei in vivo. Aplasmomycin is a symmetrical dimer related to boromycin, q.v., the only other known natural product that contains boron. Structure, x-ray crystallography: H. Nakamura et al., J. Antibiot. 30, 714 (1977). Total synthesis of (+)-form: E. J. Corey et al., J. Am. Chem. Soc. 104, 6816, 6818 (1982); T. Nakata et al., Tetrahedron Lett. 27, 6341, 6345 (1986); J. D. White et al., J. Am. Chem. Soc. 108, 8105 (1986). Use as growth promotant in ruminants: D. H. Davies et al., EP 2893; eidem, US 4225593 (1979, 1980 both to ICI). Two minor components, aplasmomycins B and C, have also been isolated from the fermentation; both aplasmomycin and aplasmomycin B show ionophoric properties, mediating net K+ transport across a bulk phase: K. Sato et al., J. Antibiot. 31, 632 (1978). NMR analysis of aplasmomycin and deboroaplasmomycin: T. S. S. Chen et al., ibid. 33, 1316 (1980). Comparative anti-anaerobic activity of aplasmomycin: K. Watanabe et al., Antimicrob. Agents Chemother. 19, 519 (1981). Structural studies: T. J. Stout et al., Tetrahedron 47, 3511 (1991). Review of biosynthetic studies: H. G. Floss, C. Chang in Antibiotics IV, J. W. Corcoran, Ed. (Springer-Verlag, New York, 1981) pp 203-210.