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Methaphenilene CAS Registry Number: 493-78-7 美沙芬林

CAS Name: N,N-Dimethyl-N'-phenyl-N'-(2-thienylmethyl)-1,2-ethanediamine
Additional Names: N,N-dimethyl-N'-phenyl-N'-(2-thenyl)ethylenediamineTrademarks: Diatrin base (Warner-Chilcott)
Percent Composition: C 69.19%, H 7.74%, N 10.76%, S 12.31%

📌 参考资料/链接：
Literature References: Prepd by a sodamide condensation of N,N-dimethyl-N¢-phenylethylenediamine with 2-thenyl chloride in dry toluene: Leonard, Solmssen, J. Am. Chem. Soc. 70, 2066 (1948). Pharmacology and toxicology: N. Ercoli et al., J. Pharmacol. Exp. Ther. 93, 210 (1948).

📄 详细内容

Properties: Dark yellow oil. bp7 183-185°. nD25 1.5902.
Boiling point: bp7 183-185°
Index of refraction: nD25 1.5902
Derivative Type: Hydrochloride
CAS Registry Number: 7084-07-3
Trademarks: Diatrin; Enstamine; Nilhistin
Percent Composition: C 60.69%, H 7.13%, N 9.44%, S 10.80%, Cl 11.94%
Properties: Crystals from ethanol, mp 186-187°. Freely soluble in water. Soluble in alc. LD50 in mice, guinea pigs (mg/kg): 45, 30 i.v.; 160, 140 s.c.; 550, 900 orally; in rabbits (mg/kg): 30 i.v. (Ercoli).
Melting point: mp 186-187°
Toxicity data: LD50 in mice, guinea pigs (mg/kg): 45, 30 i.v.; 160, 140 s.c.; 550, 900 orally; in rabbits (mg/kg): 30 i.v. (Ercoli)
Therap-Cat: Antihistaminic.
Therap-Cat-Vet: Antihistaminic.
Keywords: Antihistaminic; Ethylenediamine Derivatives.
Status: This monograph has been retired and is no longer subject to revision or update.
产品链接: 493-78-7››

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