Properties: Long, orthorhombic prisms from acetone, mp 114-116°. Sublimes in high vacuum at 93-110°. pK 4.35; pH of 0.0015 molar soln 10.0. Absorption spectra: Dobbie, Fox, J. Chem. Soc.
103, 1194 (1913); Fischer, Arch. Exp. Pathol. Pharmakol.
170, 623 (1933). One gram dissolves in 455 ml water, 90 ml water at 80°, 2 ml alc, 1.2 ml alc at 60°, 27 ml glycerol, 25 ml ether, 1 ml chloroform; also sol in benzene, dil acids. LD50 orally in rats: 750 mg/kg (Cahen, Tvede).
Melting point: mp 114-116°
pKa: pK 4.35; pH of 0.0015 molar soln 10.0
Toxicity data: LD50 orally in rats: 750 mg/kg (Cahen, Tvede)
Derivative Type: Methylbromide
CAS Registry Number: 2870-71-5
Additional Names: Methylatropine bromide
Trademarks: Tropin (Takeda)
Percent Composition: C 56.25%, H 6.82%, N 3.64%, O 12.49%, Br 20.79%
Properties: Crystals, mp 222-223°. Sol in 1 part water; slightly sol in alc. Almost insol in chloroform, ether.
Melting point: mp 222-223°
Derivative Type: Methylnitrate
CAS Registry Number: 52-88-0
Additional Names: Methylatropine nitrate
Trademarks: Eumydrin (SKB)
Percent Composition: C 59.00%, H 7.15%, N 7.65%, O 26.20%
Properties: Crystals, mp 163°. Freely sol in water or alc, very slightly in chloroform, ether.
Melting point: mp 163°
Derivative Type: Sulfate monohydrate
CAS Registry Number: 5908-99-6; 55-48-1 (anhydrous)
Trademarks: Atropisol (Novartis); Atropt (Sigma)
Percent Composition: C 58.77%, H 7.25%, N 4.03%, O 25.33%, S 4.61%
Properties: Granules or powder, mp 190-194°. Almost inactive optically. Very bitter. pH ~5.4. One gram dissolves in 0.4 ml water; 5 ml cold, 2.5 ml boil. alc; in 2.5 ml glycerol, 420 ml chloroform, 3000 ml ether. Bitterness threshold 1:10,000. Incompatible with alkalies, tannin, salts of mercury or gold, vegetable decoctions or infusions, borax, bromides, iodides, benzoates. LD50 orally in rats: 622 mg/kg (Goldenthal).
Melting point: mp 190-194°
Toxicity data: LD50 orally in rats: 622 mg/kg (Goldenthal)
Derivative Type: N-Oxide
CAS Registry Number: 4438-22-6
Additional Names: Atropine aminoxide; aminoxytropine tropate; genatropine
Percent Composition: C 66.86%, H 7.59%, N 4.59%, O 20.96%
Literature References: Prepn: Polonovski, Polonovski, Bull. Soc. Chim. Fr.
39, 1147 (1926).
Properties: Crystalline powder, mp 127-128°, dec 135°. Very hygroscopic. Soluble in alc, chloroform. Practically insol in ether.
Melting point: mp 127-128°
CAUTION: Causes blurred vision, suppressed salivation, vasodilation, hyperpyrexia, excitement, agitation, and delirium. See: Clinical Toxicology of Commercial Products, R. E. Gosselin et al., Eds. (Williams Wilkins, Baltimore, 5th Ed., 1984) Section III, pp 47-50.
Therap-Cat: Mydriatic; antispasmodic. In preanesthetic medication.
Therap-Cat-Vet: Mydriatic; antispasmodic. Antidote to organophosphorus insecticides.
Keywords: Mydriatic; Antimuscarinic; Antispasmodic.
产品链接: 51-55-8››