Zaldaride CAS Registry Number: 109826-26-8 1,3-二氢-1-[1-[(4-甲基-4H,6H-吡咯并[1,2-a][4,1]苯并氮杂-4-基)甲基]-4-哌啶]-2H-苯并咪唑-2-酮

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Literature References: Non-specific ion channel and calmodulin blocker. Prepn: J. W. F. Wasley, J. Norman, EP 233483; eidem, US 4758559 (1987, 1988 both to Ciba-Geigy). Synthesis: S. Boyer et al., J. Heterocycl. Chem. 25, 1003 (1988). Calmodulin inhibition: J. A. Norman et al., Mol. Pharmacol. 31, 535 (1987); and ion channel inhibition: R. Neuhaus, B. F. X. Reber, Eur. J. Pharmacol. 226, 183 (1992). Inhibition of gastric acid secretion: E. W. Black et al., J. Pharmacol. Exp. Ther. 248, 208 (1988); of secretory diarrhea in mice and rats: J. E. Shook et al., ibid. 251, 247 (1989). LC determn in human plasma: D. Chollet, M. Salanon, J. Chromatogr. 593, 73 (1992). Clinical trial in travelers' diarrhea: H. L. DuPont et al., Gastroenterology 104, 709 (1993).