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Dexmedetomidine CAS Registry Number: 113775-47-6 右美托嘧啶


CAS Name: 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
Additional Names: d-medetomidinePercent Composition: C 77.96%, H 8.05%, N 13.99%
📌 参考资料/链接:
Literature References: a2-Adrenergic agonist; (+)-isomer of medetomidine, q.v. Prepn: A. J. Karjalainen et al., GB 2206880; eidem, US 4910214 (1989, 1990 both to Farmos). Physical properties: R. Rajala et al., Eur. J. Pharm. Sci. 1, 219 (1994). Clinical pharmacokinetics: P. Talke et al, Anesth. Analg. 85, 1136 (1997). Clinical evaluation as anesthetic adjunct: J. Jalonen et al., Anesthesiology 86, 331 (1997). Review of pharmacology and clinical experience for sedation of patients in intensive care: N. Bhana et al., Drugs 59, 263-270 (2000).

📄 详细内容


Derivative Type: Hydrochloride
CAS Registry Number: 145108-58-3
Trademarks: Precedex (Abbott)
Percent Composition: C 67.60%, H 6.89%, N 11.26%, Cl 14.25%
Properties: White or almost white crystalline powder, mp 156.5-157.5°. d 1.17 g/cm3. [a] +52.4° (c = 1 in water). pH of 1% soln in water: 4.3.
Melting point: mp 156.5-157.5°
Optical Rotation: [a] +52.4° (c = 1 in water)
Density: d 1.17 g/cm3
Therap-Cat: Sedative; analgesic.
Keywords: a-Adrenergic Agonist; Sedative/Hypnotic.
产品链接: 113775-47-6››