Properties: Crystals from ethanol-ethyl acetate, mp 130-132°. uv max (methanol): 240, 325 nm (e 8400, 19600); (water): 260, 314 nm (e 11820, 15790). pKa1 2.1; pKa2 6.8. Partition coefficient (octanol/water): 0.3 (pH 7.4). Soly (mg/ml): chloroform 100; methanol 50.0-100.0; water 10.0-33.3; isopropanol 3.33-5.0; ethyl acetate 1.0-2.0; benzene, diethyl ether, octanol <0.5. LD50 in mice, rats (mg/kg): 265, 300 i.v.; 1685, 1680 orally (Pioch).
Melting point: mp 130-132°
pKa: pKa1 2.1; pKa2 6.8
Log P: Partition coefficient (octanol/water): 0.3 (pH 7.4)
Absorption maximum: uv max (methanol): 240, 325 nm (e 8400, 19600); (water): 260, 314 nm (e 11820, 15790)
Toxicity data: LD50 in mice, rats (mg/kg): 265, 300 i.v.; 1685, 1680 orally (Pioch)
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Histamine H2-Receptor Antagonist.
产品链接: 76963-41-2››