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Acemetacin CAS Registry Number: 53164-05-9 阿西美辛

CAS Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester
Additional Names: [[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetoxy]acetic acidTrademarks: Acemix (Bioprogress); Emflex (Merck KGaA); Rantudil (Bayer); Solart (Bioindustria)
Percent Composition: C 60.66%, H 4.36%, Cl 8.53%, N 3.37%, O 23.09%

📌 参考资料/链接：
Literature References: Deriv of indomethacin, q.v. Prepn: K. H. Boltze et al., DE 2234651; eidem, US 3910952 (1972, 1975 both to Troponwerke). Series of articles on chemistry, analysis, pharmacodynamics, toxicology and clinical trials: Arzneim.-Forsch. 30, 1313-1468 (1980). Toxicity data: H. Jacobi, H.-D. Dell, ibid. 1398.

📄 详细内容

Properties: Very fine pale yellow crystals from petr ether, mp 150-153°. LD50 in male, female mice, male, female rats (mg/kg): 55.5, 18.42, 24.2, 30.1 orally; 34.1, 51.1, 38.1, 28.3 i.v. (Jacobi, Dell).
Melting point: mp 150-153°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 55.5, 18.42, 24.2, 30.1 orally; 34.1, 51.1, 38.1, 28.3 i.v. (Jacobi, Dell)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.
产品链接: 53164-05-9››

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