Pamicogrel CAS Registry Number: 101001-34-7
CAS Name: 2-[4,5-Bis(4-methoxyphenyl)-2-thiazolyl]-1H-pyrrole-1-acetic acid ethyl ester
Additional Names: ethyl 2-[4,5-bis(p-methoxyphenyl)-2-thiazolyl]pyrrole-1-acetatePercent Composition: C 66.94%, H 5.39%, N 6.25%, O 14.27%, S 7.15%
📌 参考资料/链接：
Literature References: Cyclooxygenase inhibitor. Prepn: K. Yoshino et al., EP 159677; eidem, US 4659726 (1985, 1987 both to Kanebo). HPLC determn in plasma and urine: Y. Nakada et al., Chem. Pharm. Bull. 38, 1093 (1990). Pharmacokinetics: Y. Nakada et al., Yakuzaigaku 53, 210 (1993), C.A. 120, 315100 (1993). Activity as antithrombotic: K. Yokoto et al., Jpn. J. Pharmacol. 68, 201 (1995); as platelet aggregation inhibitor: K. Yokoto et al., J. Pharm. Pharmacol. 47, 768 (1995). Evaluation of cerebral protective effects: N. Yamamoto et al., Jpn. J. Pharmacol. 69, 421 (1995); eidem, Eur. J. Pharmacol. 297, 225 (1996).
📄 详细内容
Properties: Crystals from ligroin, mp 132.5-135.5°. LD50 orally in male mice: 3000 mg/kg (Yoshino).
Melting point: mp 132.5-135.5°
Toxicity data: LD50 orally in male mice: 3000 mg/kg (Yoshino)
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic.
产品链接: 101001-34-7››