其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

a -Spinasterol CAS Registry Number: 481-18-5 alpha-菠菜甾醇

CAS Name: (3b,5a,22E)-Stigmasta-7,22-dien-3-ol
Additional Names: a-spinasterin; bessisterol; hitodesterol
Percent Composition: C 84.40%, H 11.72%, O 3.88%
Literature References: Stereoisomeric with chondrillasterol, q.v. Extracted from spinach leaves: Hart, Heyl, J. Biol. Chem. 95, 311 (1932); from Citrullus colocynthis Schrad., Cucurbitaceae: Hamilton, Kermack, J. Chem. Soc. 1952, 5051. Structure: Fieser et al., J. Am. Chem. Soc. 71, 2226 (1949). Prepn: Kircher, Rosenstein, J. Org. Chem. 38, 2259 (1973); M. Anastasia et al., J. Chem. Soc. Perkin Trans. 1 1981, 2561.

Pseudotropine CAS Registry Number: 135-97-7 β-托品醇

CAS Name: exo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
Additional Names: 1aH,5aH-tropan-3b-ol; 3b-tropanol; y-tropine; 3-pseudotropanol
Percent Composition: C 68.04%, H 10.71%, N 9.92%, O 11.3...
Literature References: Stereoisomeric with tropine. Prepn, structure, separation from tropine, and stereochemical configuration: See Tropine. Stereochemical synthesis: J. J. Tufariello et al., J. Am. Chem. Soc. 101, 2435 (1979).

Crabtree's Catalyst CAS Registry Number: 64536-78-3 (1,5-环辛二烯)(嘧啶)(三环己基膦)铱(I)六氟磷酸盐

CAS Name: [(1,2,5,6-h)-1,5-Cyclooctadiene](pyridine)(tricyclohexylphosphine)iridium(1+) hexafluorophosphate(1-)
Additional Names: Felkin-Crabtree catalyst
Percent Composition: C 46.26%, H 6....
Literature References: Stereoselective organoiridium based catalyst used primarily for hydrogenation of the general formula [Ir(cod)L(py)]metal complex where cod is 1,5-cyclooctadiene, L is tertiary phosphine, py is pyridine. Prepn: R. H. Crabtree, G. E. Morris, J. Organomet. Chem. 135, 395 (1977); R. H. Crabtree et al., ibid. 141, 205 (1977); R. H. Crabtree, S. M. Morehouse, Inorg. Synth. 24, 173 (1986). Hydrogenation study: J. W. Suggs et al., Tetrahedron Lett. 22, 303 (1981); directing effects: J. M. Brown, S. A. Hall, Tetrahedron 41, 4639 (1985); R. H. Crabtree, M. W. Davis, J. Org. Chem. 51, 2655 (1986). Structure: M. S. Abbassioun et al., Acta Crystallogr. C45, 331 (1989). Synthetic applications: M. Weck et al., J. Org. Chem. 64, 5463 (1999); J. M. Bueno et al., Tetrahedron Lett. 41, 4379 (2000).

Iron Sorbitex CAS Registry Number: 1338-16-5

CAS Name: Glucitol iron complex, compd with citric acid
Additional Names: iron sorbitol; iron sorbitol citrate
Trademarks: Jectofer (AstraZeneca)
Literature References: Sterile soln (pH 7.2-7.9) of a complex of iron, sorbitol, and citric acid, stabilized with dextrin in a dil soln of sorbitol. Contains 50 ±2 mg/ml of elemental iron. Average mol wt <5000. Prepn: Lindvall, Andersson, Br. J. Pharmacol. Chemother. 17, 358 (1961).

Sarsasapogenin CAS Registry Number: 126-19-2 菝葜皂苷元; 菝葜皂甙元

CAS Name: (3b,5b,25S)-Spirostan-3-ol
Additional Names: parigenin
Percent Composition: C 77.83%, H 10.64%, O 11.52%
Literature References: Steroid sapogenin from Smilax ornata Hooker, fil., Liliaceae (Sarsaparilla): Power, Salway, J. Chem. Soc. 105, 201 (1914); Jacobs, Simpson, J. Biol. Chem. 105, 501 (1934); 109, 573 (1935). Partial structure: Hirschmann et al., J. Org. Chem. 20, 572 (1955). Stereochemistry: Taylor, Chem. Ind. (London) 1954, 1066; Wall, Serota, J. Am. Chem. Soc. 76, 2850 (1954); Callow, Massey-Beresford, J. Chem. Soc. 1957, 4482; Rosen et al., J. Am. Chem. Soc. 81, 1687 (1959). Reviews: Turner, The Steroidal Sapogenins Pub. no. 361, (Univ. Microfilms, Ann Arbor, Mich., 1941) 249 pp; Shabica, Sarsasapogenin and Related Compounds, Univ. Microfilms (Ann Arbor, Mich.), Pub. no. 549, 89 pp (1943); L. F. Fieser, M. Fieser, Steroids (Reinhold, New York, 1959) p 810. See also Smilagenin.

Jervine CAS Registry Number: 469-59-0 蒜藜芦碱

CAS Name: (3b,23b)-17,23-Epoxy-3-hydroxyveratraman-11-one
Percent Composition: C 76.20%, H 9.24%, N 3.29%, O 11.28%
Literature References: Steroidal alkaloid found in Veratrum grandiflorum (Maxim.) Loes F., V. album L., V. viride Sol., Liliaceae: Saito, Bull. Chem. Soc. Jpn. 9, 15 (1934), C.A. 28, 2463 (1934); Poethke, Arch. Pharm. 275, 357, 571 (1937); 276, 170 (1938); 282, 56 (1944); Seiferle et al., J. Econ. Entomol. 35, 35 (1942); Jacobs, Craig, J. Biol. Chem. 160, 555 (1945). Structure: Fried et al., J. Am. Chem. Soc. 73, 2970 (1951). Reviews: Wintersteiner in Graff, Essays in Biochemistry (Wiley, New York, 1956) pp 308-321; idem, Festschrift Arthur Stoll (Basel, 1957) pp 166-176; L. F. Fieser, M. Fieser, Steroids (Reinhold, New York, 1959) pp 870-877. Stereochemistry: Sicher, Tichy, Tetrahedron Lett. no. 12, 6 (1959); Augustine, Chem. Ind. (London) 196l, 1448; Mitsuhashi, Shimizu, Tetrahedron 19, 1027 (1963); Bailey et al., Tetrahedron Lett. 1963, 555; Masamune et al., ibid. 1965, 489. Revised stereochemistry: Scott et al., ibid. 1967, 2381; Kupchan, Suffness, J. Am. Chem. Soc. 90, 2730 (1968); Sprague et al., Tetrahedron 27, 4857 (1971). Total synthesis: Kutney et al., Can. J. Chem. 53, 1796 (1975). Comparative toxicity: O. Krayer et al., J. Pharmacol. Exp. Ther. 82, 167 (1944); K. Tanaka, ibid. 113, 89 (1955).

Funtumine CAS Registry Number: 474-45-3 丝胶树碱

CAS Name: (3a,5a)-3-Aminopregnan-20-one
Additional Names: 3a-amino-20-oxo-5a-pregnane
Percent Composition: C 79.44%, H 11.11%, N 4.41%, O 5.04%
Literature References: Steroidal alkaloid isolated from Funtumia latifolia Stapf., Apocynaceae: Janot et al., C.R. Hebd. Seances Acad. Sci. 246, 3076 (1958); from leaves of Holorrhena febrifuga Stapf., Apocynaceae: H. Dodoun et al., Phytochemistry 12, 923 (1973). Structure: Janot et al., Bull. Soc. Chim. Fr. 1960, 1640, 1669. Prepn: H. Kapnang et al., Tetrahedron Lett. 1977, 3469. Review: R. Goutarel, Bull. Soc. Chim. Fr. 1960, 769. Effect on liver carcinogenesis in rats: A. Lacassagne et al., C.R. Seances Acad. Sci. Ser. D 274, 2830 (1972).

Solasodine CAS Registry Number: 126-17-0 澳洲茄胺; 澳州茄胺

CAS Name: (3b,22a,25R)-Spirosol-5-en-3-ol
Additional Names: solasod-5-en-3b-ol; D5-20bF,22aF,25aF,27-azaspirosten-3b-ol; solancarpidine; solanidine-S; purapuridine
Percent Composition: C 78....
Literature References: Steroidal alkaloid isolated from various Solanum species. By hydrolysis of solasonine: Rochelmeyer, Arch. Pharm. 277, 329 (1939). See also ref under Solasonine and Solanidine. Structure: Briggs et al., J. Chem. Soc. 1950, 3013. Synthesis: Uhle, J. Org. Chem. 27, 656 (1962); Schreiber, Rönsch, Tetrahedron 20, 1939 (1964); Kessar et al., ibid. 27, 2869 (1971). Comprehensive description: G. Indrayanto et al., Anal. Profiles Drug Subs. Excip. 24, 487-522 (1996).

Veralkamine CAS Registry Number: 17155-31-6 (3beta,16beta,17alpha)-10,17-二甲基-17-{(1S)-1-[(2S)-5-甲基-2-哌啶基]乙基}性甾-5,12-二烯-3,16-二醇

CAS Name: (3b,16b,17a,22a)-17-Methyl-18-nor-16,28-secosolanida-5,12-diene-3,16-diol
Additional Names: 17-methyl-20a-((2S,5S)-5-methyl-2-piperidyl)-18-nor-17a-pregna-5,12-diene-3b,16b-diol; (22S...
Literature References: Steroidal alkaloid isolated from Veratrum album sp. lobelianium (Bernh.) Suessenguth, Liliaceae: Tomko et al., Pharm. Zentralhalle 99, 373 (1960), C.A. 55, 2013e. Structure studies: Tomko et al., Collect. Czech. Chem. Commun. 27, 1404 (1962). Complete structure: Tomko et al., Tetrahedron Lett. 1967, 3907; eidem, Tetrahedron 24, 4865 (1968); Hoehne et al., ibid. 4875.

Gestrinone CAS Registry Number: 16320-04-0 孕三烯酮

CAS Name: (17a)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one
Additional Names: 13b-ethyl-17a-ethynyl-17b-hydroxy-4,9,11-gonatrien-3-one; 13b-ethyl-17a-ethynyl-D4,9,11-gonatrie...
Literature References: Steroidal antiestrogen, antiprogestogen, analog of norgestrienone, q.v. Prepn: G. Nomine et al., US 3257278; NL 6607609 C.A. 67, 44029d (1967); D. Bertin, A. Pierdet, US 3478067 (1966, 1966, 1969 all to Roussel-UCLAF). Radioimmunoassay in human plasma: J. Frick et al., Urol. Res. 5, 55 (1977). HPLC-MS-MS determn in plasma: Q. Wang et al., J. Chromatogr. B 746, 151 (2000). Clinical evaluation of contraceptive efficacy: G. Azadian-Boulanger et al., Am. J. Obstet. Gynecol. 125, 1049 (1976); of use in fibrocystic breast disease: E. M. Coutinho, G. Azadian-Boulanger, Int. J. Gynaecol. Obstet. 22, 363 (1984); in endometriosis: E. J. Thomas, I. D. Cooke, Br. Med. J. 294, 272 (1987); E. M. Coutinho, G. Azadian-Boulanger, Fertil. Steril. 49, 418 (1988).