其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Erythritol CAS Registry Number: 149-32-6 赤藓糖醇

CAS Name: (2R,3S)-rel-1,2,3,4-Butanetetrol
Additional Names: meso-erythritol; tetrahydroxybutane; erythrol; erythrite; antierythrite; erythroglucin; phycite
Percent Composition: C 39.34%, H ...
Literature References: All natural bulk sweetener found in various fruits and fermented foods; 60 to 70% as sweet as sucrose. Isoln from algae, lichens, grasses: Bamberger, Landsiedl, Monatsh. Chem. 21, 571 (1900); Hesse, J. Prakt. Chem. 92, 425 (1915); Hofmann, Ber. 7, 508 (1874). Prepn by Aspergillus niger: Yuill, Nature 162, 652 (1948); by Penicillium herquei: Galarraga et al., Biochem. J. 61, 456 (1955); from 2-butene-1,4-diol: Reppe, Schnabel, DE 734025 (1943 to I. G. Farbenind.); from periodate-oxidized starch: Jeanes, Hudson, J. Org. Chem. 20, 1565 (1955). Structure: Shimada, Acta Crystallogr. 11, 748 (1958). Review of metabolism, toxicology and clinical safety studies: I. C. Munro et al., Food Chem. Toxicol. 36, 1139-1174 (1998); of use in beverage industry: P. de Cock, C.-L. Bechert, Pure Appl. Chem. 74, 1281-1289 (2002).

Canthaxanthin CAS Registry Number: 514-78-3 斑蝥黄(反式)

CAS Name: b,b-Carotene-4,4'-dione
Additional Names: 4,4'-dioxo-b-carotene; Food Orange 8; C.I. 40850
Trademarks: Carophyll Red (Roche); Orobronze (Applipharm); Roxanthin Red 10 (Roche); Caro...
Literature References: All trans-carotenoid pigment widely distributed in nature. Isoln from the edible mushroom Cantharellus cinnabarinus Adans. ex Fr., Agaricaceae: Haxo, Bot. Gaz. 112, 228 (1950); also isolated from flamingo feathers. Structure and synthesis: Isler et al., Verh. Naturforsch. Ges. Basel 67, 379 (1956); Zeller et al., Helv. Chim. Acta 42, 841 (1959). Alternate syntheses: M. Akhtar, B. C. L. Weedon, J. Chem. Soc. 1959, 4058; R. Rüegg, G. Saucy, US 2983752 and J. D. Surmatis, US 3311656 (1961, 1967 both to Hoffmann-La Roche); J. D. Surmatis et al., Helv. Chim. Acta 53, 974 (1970); M. Rosenberger et al., Pure Appl. Chem. 51, 871 (1979); eidem, J. Org. Chem. 47, 2130 (1982).

Efaproxiral CAS Registry Number: 131179-95-8 乙丙昔罗

CAS Name: 2-[4-[2-[(3,5-Dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoic acid
Additional Names: 2-4-[[(3,5-dimethylanilino)carbonyl]methyl]phenoxy-2-methylpropionic acidPercent Compo...
Literature References: Allosteric modifier of hemoglobin (Hb). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Prepd not claimed: D. J. Abraham et al., US 5049695 (1991 to Center Innovative Technol.); eidem., J. Med. Chem. 34, 752 (1991). Oxygen binding affinities and mechanism of action: D. J. Abraham et al., Biochemistry 31, 9141 (1992). Effect on myocardial oxygen concentration: P. S. Pagel et al., J. Pharmacol. Exp. Ther. 285, 1 (1998). Antimetastatic effects: B. A. Teicher et al., Cancer Chemother. Pharmacol. 42, 24 (1998). Clinical pharmacokinetics and pharmacodynamics: L. Kleinberg et al., J. Clin. Oncol. 17, 2593 (1999). Clinical evaluation in brain tumor therapy: eidem, ibid. 20, 3149 (2002).

Potassium Tetraiodomercurate(II) CAS Registry Number: 7783-33-7 碘化汞钾

Additional Names: Mercuric potassium iodide
Percent Composition: Hg 25.51%, I 64.55%, K 9.94%
Literature References: Also crystallizes with 1-2 mols H2O.

Paraformaldehyde CAS Registry Number: 30525-89-4 多聚甲醛

Additional Names: Polyoxymethylene
Trademarks: Paraform; Formagene
Literature References: Also erroneously referred to as Triformol or as "trioxymethylene". Polymerized formaldehyde, (CH2O)n. Obtained by concentrating formaldehyde soln. Use in mummifying dental pulp: I. Curson, Br. Dent. J. 121, 519 (1966); P. Hobson, ibid. 128, 275 (1970).

Nickel Acetylacetonate CAS Registry Number: 3264-82-2 乙酰丙酮镍

CAS Name: Bis(2,4-pentanedionato-O,O')nickel
Additional Names: bisacetylacetonatonickel(II); bis(2,4-pentanediono)nickel(II); 2,4-pentanedione nickel complex
Percent Composition: C 46.75%, H...
Literature References: Also Ni(acac)2 or Ni(AA)2. Prepn from acetylacetone and Ni(OH)2: Gach, Monatsh. Chem. 21, 103 (1900); from acetylacetone and NiCl2.6H2O: Charles, Pawlikowski, J. Phys. Chem. 62, 440 (1958); from 4-diethylamino-3-pentene-2-one and NiCl2.6H2O: Gash, Can. J. Chem. 45, 2109 (1967). See also Fernelius, Bryant, Inorg. Synth. 5, 105 (1957). Exists as a trimer in the solid state: Bullen, Nature 177, 537 (1956); Bullen et al., Inorg. Chem. 4, 456 (1965); as a monomer in the vapor phase: Fackler et al., J. Phys. Chem. 72, 4631 (1972). Structure of dihydrate: Montgomery, Lingafelter, Acta Crystallogr. 17, 1481 (1964).

o-Phthalaldehyde CAS Registry Number: 643-79-8 邻苯二甲醛

CAS Name: 1,2-Benzenedicarboxaldehyde
Additional Names: o-phthaldialdehyde
Trademarks: Cidex OPA (J J)
Percent Composition: C 71.64%, H 4.51%, O 23.86%
Literature References: Alternative to glutaraldehyde, q.v. for high-level disinfenction. Prepn: A. Colson, H. Gautier, Bull. Soc. Chim. 45, 509 (1886); J. Thiele, O. Günther, Ann. 347, 106 (1906); T. C. Chaudhuri, J. Am. Chem. Soc. 64, 315 (1942). Polarographic determn: N. H. Furman, D. R. Norton, Anal. Chem. 26, 1111 (1954). Use in fluorogenic determn of peptides: M. Roth, ibid. 43, 880 (1971); T. M. Joys, H. Kim, Anal. Biochem. 94, 371 (1979); of biological thiols: K. Mopper, D. Delmas, Anal. Chem. 56, 2557 (1984). Biocidal properties: S. E. Walsh et al., J. Appl. Microbiol. 86, 1039 (1999). Mechanism of antibacterial action: idem et al., ibid. 87, 702 (1999). Bactericidal efficacy study: J. C. N. Shackelford et al., J. Antimicrob. Chemother. 57, 335 (2006). Hospital disinfection of endoscopes: S. M. Hession, Gastroenterol. Nurs. 26, 110 (2003). Review of reactivity with nucleophiles: P. Zuman, Chem. Rev. 104, 3217-3238 (2004).

Hendrickson's Reagent CAS Registry Number: 72450-51-2

CAS Name: m-Oxohexaphenyldiphosphorus(2+) salt with trifluoromethanesulfonic acid (1:2)
Additional Names: triphenylphosphonium anhydride trifluoromethanesulfonate; POP
Percent Composition: C...
Literature References: Alternative to Mitsunobu reagents for the esterification of primary alcohols. Synthesis method: J. B. Hendrickson, S. M. Schwartzman, Tetrahedron Lett. 16, 277 (1975). Prepn: A. Aaberb et al., ibid. 20, 2263 (1979). Synthetic applications as a dehydration agent: J. B. Hendrickson, Md. S. Hussoin, J. Org. Chem. 52, 4137 (1987); eidem et al., Synlett 1996, 661; and X-ray crystal structure determn: S.-L. You et al., Angew. Chem. Int. Ed. 42, 83 (2003). Mechanism of dehydration reactions vs the Mitsunobu reaction: K. E. Elson et al., Org. Biomol. Chem. 1, 2958 (2003).

Sermorelin CAS Registry Number: 86168-78-7 舍莫瑞林

Additional Names: Human growth hormone-releasing factor(1-29)amide; human pancreatic somatoliberin(1-29)amide; GRF(1-29)NH2; hpGRF(1-29)NH2Trademarks: Geref (Serono); Groliberin (Kabi)
Percent ...
Literature References: Amidated fragment of human somatoliberin, q.v. Characterization of in vitro activity: J. Rivier et al., Nature 300, 276 (1982). Prepn: N. Ling et al., Biochem. Biophys. Res. Commun. 123, 854 (1984); J. E. F. Rivier et al., US 4703035 (1987 to Salk Inst. Biol. Stud.). Clinical pharmacology: M. Losa et al., Klin. Wochenschr. 62, 1140 (1984). Clinical evaluation in growth hormone deficiency: M. B. Ranke et al., Eur. J. Pediatr. 145, 485 (1986); R. Hümmelink et al., Acta Paediatr. Scand. Suppl. 331, 48 (1987). Field trial in pigs and dairy heifers: D. Petitclerc et al., J. Anim. Sci. 65, 996 (1987).

Alibendol CAS Registry Number: 26750-81-2 阿利苯多

CAS Name: 2-Hydroxy-N-(2-hydroxyethyl)-3-methoxy-5-(2-propenyl)benzamide
Additional Names: 5-allyl-2-hydroxy-N-(2-hydroxyethyl)-m-anisamide; 2-hydroxy-3-methoxy-5-allyl-N-(b-hydroxyethyl)benzam...
Literature References: Amide analog of eugenol, q.v. Prepn: FR 1584715; F. Clémence, O. Le Martret, US 3668238 (1967, 1972 both to Roussel). Synthesis and pharmacologic activity: F. Clémence et al., Chim. Ther. 5, 188 (1970).