其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

EGCG CAS Registry Number: 989-51-5 (-)-表没食子儿茶素没食子酸酯

CAS Name: 3,4,5-Trihydroxybenzoic acid, (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester
Additional Names: (-)-epigallocatechin 3-O-gallate; (-)-epigalloc...
Literature References: Polyphenolic constituent of tea; inhibits tumor promotion. Initial identification and isoln from green tea: M. Tsujimura, Bull. Agric. Chem. Soc. Jpn. 6, 70 (1930); C.A. 25, 3637 (1931); and crystallization: L. Vuataz et al., J. Chromatogr. 2, 173 (1959). Oxidation during tea fermentation: P. Coggon et al., J. Agric. Food Chem. 21, 727 (1973). HPLC/MS extraction from black tea: R. G. Bailey et al., J. Sci. Food Agric. 66, 203 (1994). HPLC determn in plasma and urine: M.-J. Lee et al., Cancer Epidemiol. Biomarkers Prev. 4, 393 (1995). Antitumor promoting activity: S. Yoshizawa et al., Phytother. Res. 1, 44 (1987); T. Yamane et al., Cancer Res. 55, 2081 (1995). Inhibition of metastasis in mice: S. Taniguchi et al., Cancer Lett. 65, 51 (1992). Modulation of endocrine systems and food intake: Y.-H. Kao, et al., Endocrinology 141, 980 (2000).

g -Linolenic Acid CAS Registry Number: 506-26-3 γ-亚麻酸

CAS Name: (6Z,9Z,12Z)-6,9,12-Octadecatrienoic acid
Additional Names: cis-6,cis-9,cis-12-octadecatrienoic acid; gamolenic acid; GLA
Trademarks: Viacutan (Boehringer, Ing.)
Percent Composit...
Literature References: Polyunsaturated fatty acid produced in the body as the D6-desaturase metabolite of linoleic acid, q.v. Converted to dihomo-g-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. Present to varying extents in the fatty acid fraction of evening primrose oil (7-10%), in borage oil (18-26%), in black currant oil (15-20%) and in oils from different fungal sources (6-24%). Isoln from evening primrose oil, q.v.: A. Heiduschka, K. Luft, Arch. Pharm. 257, 33 (1919). Proposed structure: Eibner et al., Chem. Umschau. 34, 312 (1927). Confirmation of structure: J. P. Riley, J. Chem. Soc. 1949, 2728. Discussion of occurrence, esp. in fungi: R. Shaw, Biochim. Biophys. Acta 98, 230 (1965). Synthesis: J. M. Osbond et al., J. Chem. Soc. 1961, 2779; J. M. Osbond, ibid. 5270. Metabolism studies: J. F. Mead, D. R. Howton, J. Biol. Chem. 229, 575 (1957); K. J. Stone et al., Lipids 14, 174 (1979). Effect of source on essential fatty acid and prostanoid metabolite formation: D. K. Jenkins et al., Med. Sci. Res. 16, 525 (1988).

Polyvinyl Chloride CAS Registry Number: 9002-86-2 聚氯乙烯

CAS Name: Chloroethene homopolymer
Additional Names: chloroethylene polymer; PVC
Trademarks: Geon (Goodrich); Breon; Welvic (European Vinyls); Movyl (Montecatini); Tevilon (Teikoku Rayon); K...
Literature References: Polyvinyl chloride fibers are marketed under the names: Rhovyl (Rhovyl) , Fibravyl (Rhovyl) , Thermovyl (Rhovyl) , Isovyl (Rhovyl) , Retractyl (Rhovyl) , Crinovyl (Rhovyl) , Envilon (Toyo) , Nip (Nichay) . Average mol wt ~60,000 to 150,000. Prepn: Baumann, Ann. 163, 308 (1872); Schoenfeld, US 2168808 (1937 to B. F. Goodrich). Structure: Natta, Rigamonti, Atti Accad. Naz. Lincei Cl. Sci. Fis. Mat. Nat. Rend. 24, 381 (1936); C.A. 31, 45639 (1937); Marvel et al., J. Am. Chem. Soc. 61, 3241 (1939). Reviews: C. E. Schildknecht, Vinyl and Related Polymers (Wiley, New York, 1952) pp 392-442. Technology: W. S. Penn, PVC Technology (Maclaren, London, 1962); J. A. Davidson, K. L. Gardner, "Vinyl Polymers (PVC)" in Kirk-Othmer Encyclopedia of Chemical Technology vol. 23 (Wiley-Interscience, New York, 3rd ed., 1983) pp 886-936. Book: Sarvetnick, Polyvinyl Chloride (Van Nostrand, Reinhold, New York, 1969).

Azafenidin CAS Registry Number: 68049-83-2 唑啶草酮

CAS Name: 2-[2,4-Dichloro-5-(2-propynyloxy)phenyl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridin-3(2H)-oneTrademarks: Milestone (DuPont); Evolus (DuPont)
Percent Composition: C 53.27%, H 3.87...
Literature References: Porphyrin biosynthesis inhibitor. Prepn: A. D. Wolf, BE 862884; idem, US 4213773 (1978, 1980 both to Du Pont). Review of physical properties, mode of action, and activity: K. Amuti et al., Brighton Crop Prot. Conf. - Weeds 1997, 59-66.

Pimobendan CAS Registry Number: 74150-27-9 匹莫苯丹

CAS Name: 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone
Additional Names: UD-CG 115; UD-CG 115 BS; 2-(4-methoxyphenyl)-5(6)-(5-methyl-3-oxo-4,5-dihydro-2H...
Literature References: Positive inotropic agent. Prepn: V. Austel et al., DE 2837161; eidem, US 4361563 (1980, 1982 both to Thomae). Cardiovascular effects: J. C. A. von Meel, Arzneim.-Forsch. 35, 284 (1985); P. D. Verdouw et al., Eur. J. Pharmacol. 126, 21 (1986). Comparison of enantiomer activity: K. Fujino et al., J. Pharmacol. Exp. Ther. 247, 519 (1988). Clinical trial in congestive heart failure: F. Hagemeijer, Am. Heart J. 122, 517 (1991); S. D. Katz et al., ibid. 123, 95 (1992).

Vesnarinone CAS Registry Number: 81840-15-5 维司力农

CAS Name: 1-(3,4-Dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)piperazine
Additional Names: 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone; 6-[4-(3,4-dime...
Literature References: Positive inotropic agent. Prepn: Y. H. Yang et al., BE 890942; M. Tominaga et al., US 4415572 (1982, 1983 both to Otsuka); M. Tominaga et al., Chem. Pharm. Bull. 32, 2100 (1984). Physicochemical properties: T. Shimizu et al., Arzneim.-Forsch. 34, 334 (1984). Series of articles on mechanism of action and pharmacology: ibid. 342-402. Effects on canine arrhythmias: K. Hashimoto, H. Mitsuhashi, Br. J. Pharmacol. 88, 915 (1986). Metabolism: G. Miyamoto et al., Xenobiotica 18, 1143 (1988). Clinical pharmacokinetics: A. Ohnishi, T. Ishizaki, J. Clin. Pharmacol. 28, 719 (1988). HPLC determn in plasma and urine: G. Miyamoto et al., J. Chromatogr. 338, 450 (1985). Clinical evaluations in congestive heart failure: H. Asanoi et al., J. Am. Coll. Cardiol. 9, 865 (1987); A. M. Feldman et al., Am. Heart J. 116, 771 (1988).

Fomesafen CAS Registry Number: 72178-02-0 氟磺胺草醚

CAS Name: 5-[2-Chloro-4-(trifluoromethyl)phenoxy]-N-(methylsulfonyl)-2-nitrobenzamide
Trademarks: Flex (Syngenta); Reflex (Syngenta)
Percent Composition: C 41.06%, H 2.30%, Cl 8.08%, F 12.99...
Literature References: Post-emergence diphenyl ether herbicide used for early control of broad-leaf weeds in soybean and other legume crops. Prepn: D. Cartwright, D. J. Collins, EP 3416; eidem, US 4285723 (1979, 1981 both to Imperial Chemical Industries). Properties and field trial in soybeans: S. R. Colby, J. W. Barnes, Proc. 10th Int. Congr. Plant Prot. 1, 295 (1983); in green beans: C. M. Knott, Brighton Crop Prot. Conf. - Weeds 1993, 1053. Mode of selectivity and metabolism in plant crops and weeds: J. D. H. L. Evans et al., Proc. Br. Crop Prot. Conf. - Weeds 1987, 345. Metabolism and hepatoxicity in rodents: J. Krijt et al., Hum. Exp. Toxicol. 18, 338 (1999). Environmental fate in soils: J. B. Weber, Pestic. Sci. 39, 31 (1993); J. Guo et al., Water Air Soil Pollut. 148, 77 (2003). Ecotoxicological effects in aquatic systems: T. Caquet et al., Environ. Toxicol. Chem. 24, 1116 (2005).

Amidosulfuron CAS Registry Number: 120923-37-7 酰嘧磺隆

CAS Name: N-(4,6-Dimethoxy-2-pyrimidinyl)-3-methyl-2,4-dithia-3,5-diazahexan-6-amide 2,2,4,4-tetraoxide
Additional Names: 3-(4,6-dimethoxypyrimidin-2-yl-)-1-(
N-methyl-
N-methyl-sulfonyl)...
Literature References: Post-emergence herbicide for broad-leaf weed control in cereals. Prepn: L. Willms et al., EP 131258; eidem, US 4601747 (1985, 1986 both to Hoechst). Degradation in soil: G. Fent et al., Sci. Total Environ. 132, 201 (1993); K. L. Sagan et al., J. Agric. Food Chem. 46, 1205 (1998). Field trial in cereal crops: D. S. M. D'Souza et al., Brighton Crop Prot. Conf. - Weeds 1993, 567; for control of wild mustard in canola: K. J. Kirkland Weed Technol. 9, 541 (1995).

Dicryl CAS Registry Number: 2164-09-2 丁酰草胺

CAS Name: N-(3,4-Dichlorophenyl)-2-methyl-2-propenamide
Additional Names: 3',4'-dichloro-2-methylacrylanilide; N-(3,4-dichlorophenyl)methacrylamide; chloranocrylPercent Composition: C 52.20%, H...
Literature References: Post-emergence herbicide. Prepn from 3,4-dichloroaniline with methacryloyl chloride in the presence of triethylamine. Prepd but not claimed: Thompson, US 3169850 (1965). Toxicity study: G. W. Bailey, J. L. White, Residue Rev. 10, 97 (1965).

Nicosulfuron CAS Registry Number: 111991-09-4 烟嘧磺隆

CAS Name: 2-[[[[(4,6-Dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-N,N-dimethyl-3-pyridinecarboxamideTrademarks: Accent (DuPont); Nostoc (Ipesa)
Percent Composition: C 43.90%, H 4.42%,...
Literature References: Post-emergence sulfonylurea herbicide. Prepn: F. Kimura et al., EP 232067 (1987 to Ishihara Sangyo Kaisha); M. A. Hanagan, US 4789393 (1988 to DuPont); and structure-activity study: S. Murai et al., ACS Symp. Ser. 504, 43 (1992). Activity in soil: T. C. Mueller et al., Tenn. Farm Home Sci. 167, 17 (1993). Adsorption on clay minerals: L. Ukrainczyk, N. Rashid, J. Agric. Food Chem. 43, 855 (1995). Field trial for johnsongrass in corn and effect on yield: N. G. Gubbiga et al., Weed Technol. 9, 574 (1995).