将硼氢化钠(0.26 g,7.00 mmol)在30 mL乙醚中的溶液滴加到2-(氰基甲基)吡啶(0.80 g,6.82 mmol)和AlCl3(0.93 g,7.00 mmol)的混合物中.将溶液在室温下搅拌6小时.除去溶剂,用热异丙醚(3 x 30 mL)萃取所得混合物.合并有机层并在减压下除去溶剂得到2-(2-氨乙基)吡啶.1H NMR (CDCl3, 400 MHz) δ = 1.54 (s, 2H), 2.91 (t, 2H, J = 6.7 Hz), 3.10 (t, 2H, J = 6.7 Hz), 7.09 (ddd, 1H, J = 7.5 Hz, J = 6.1 Hz, J = 1.1 Hz), 7.14 (ddd, 1H, J = 7.9 Hz, J = 0.9 Hz, J = 0.9 Hz), 7.57 (ddd, 1H, J = 7.6 Hz, J = 7.2 Hz, J = 1.9 Hz), 8.51 (ddd, 1H, J = 4.9 Hz, J = 1.9 Hz, J = 1.0 Hz); 13C NMR (CDCl3, 100 MHz) δ = 41.9, 121.2, 123.3, 136.3, 149.3, 160.0; MS (CI, NH3) m/z = 123.1 (100) [(M + 1)+].
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