Romidepsin CAS# 128517-07-7 罗米地辛
Romidepsin, also known as FK228; is a bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation, romidepsin binds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia-induced angiogenesis and depletes several heat shock protein 90 (Hsp90)-dependent oncoproteins.
📌 参考资料/链接：
Li, Khan W.; Wu, Jerry; Xing, Wenning; Simon, Julian A. Total Synthesis of the Antitumor Depsipeptide FR-901,228. Journal of the American Chemical Society. Volume 118. Issue 30. Pages 7237-7238. 1996.
Li, Khan W.; Wu, Jerry; Xing, Wenning; Simon, Julian A. Total Synthesis of the Antitumor Depsipeptide FR-901,228. Journal of the American Chemical Society. Volume 118. Issue 30. Pages 7237-7238. 1996.
📄 详细内容
CAS No. 128517-07-7 罗米地辛Romidepsin synthetic routes
Li, Khan W.; Wu, Jerry; Xing, Wenning; Simon, Julian A. Total Synthesis of the Antitumor Depsipeptide FR-901,228. Journal of the American Chemical Society. Volume 118. Issue 30. Pages 7237-7238. 1996.
产品链接: CAS No. 128517-07-7 ››
Li, Khan W.; Wu, Jerry; Xing, Wenning; Simon, Julian A. Total Synthesis of the Antitumor Depsipeptide FR-901,228. Journal of the American Chemical Society. Volume 118. Issue 30. Pages 7237-7238. 1996.
产品链接: CAS No. 128517-07-7 ››