Venetoclax CAS# 1257044-40-8 维纳妥拉(ABT-199)
Venetoclax, also known as ABT-199 or GDC0199, is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells.
📌 参考资料/链接：
Reference: Ku, Yi-Yin; Chan, Vincent S.; Christesen, Alan; Grieme, Timothy; Mulhern, Mathew; Pu, Yu-Ming; Wendt, Michael D. Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL-2 Selective Inhibitor. Journal of Organic Chemistry. Volume 84. Issue 8. Pages 4814-4829. Journal; Online Computer File. (2019).
Reference: Ku, Yi-Yin; Chan, Vincent S.; Christesen, Alan; Grieme, Timothy; Mulhern, Mathew; Pu, Yu-Ming; Wendt, Michael D. Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL-2 Selective Inhibitor. Journal of Organic Chemistry. Volume 84. Issue 8. Pages 4814-4829. Journal; Online Computer File. (2019).
📄 详细内容
CAS No. 1257044-40-8 维纳妥拉(ABT-199)Venetoclax synthetic routes
Ku, Yi-Yin; Chan, Vincent S.; Christesen, Alan; Grieme, Timothy; Mulhern, Mathew; Pu, Yu-Ming; Wendt, Michael D. Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL-2 Selective Inhibitor. Journal of Organic Chemistry. Volume 84. Issue 8. Pages 4814-4829. Journal; Online Computer File. (2019).
产品链接: CAS No. 1257044-40-8 ››
Ku, Yi-Yin; Chan, Vincent S.; Christesen, Alan; Grieme, Timothy; Mulhern, Mathew; Pu, Yu-Ming; Wendt, Michael D. Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL-2 Selective Inhibitor. Journal of Organic Chemistry. Volume 84. Issue 8. Pages 4814-4829. Journal; Online Computer File. (2019).
产品链接: CAS No. 1257044-40-8 ››