Ribociclib CAS# 1211441-98-3 瑞博西尼
Ribociclib Free Base, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
📌 参考资料/链接：
Reference: Reddy, Peddireddy Subba; Kumar, Kottur Mohan; Oruganti, Srinivas; Kandagatla, Bhaskar; Das Gupta, Shirshendu. Process for preparation of Ribociclib and its acid addition salts. WO 2018051280. (PCT Int. Appl. (2018))
Reference: Reddy, Peddireddy Subba; Kumar, Kottur Mohan; Oruganti, Srinivas; Kandagatla, Bhaskar; Das Gupta, Shirshendu. Process for preparation of Ribociclib and its acid addition salts. WO 2018051280. (PCT Int. Appl. (2018))
📄 详细内容
CAS No. 1211441-98-3 瑞博西尼Ribociclib synthetic routes
Reddy, Peddireddy Subba; Kumar, Kottur Mohan; Oruganti, Srinivas; Kandagatla, Bhaskar; Das Gupta, Shirshendu. Process for preparation of Ribociclib and its acid addition salts. WO 2018051280. (PCT Int. Appl. (2018))
产品链接: CAS No. 1211441-98-3 ››
Reddy, Peddireddy Subba; Kumar, Kottur Mohan; Oruganti, Srinivas; Kandagatla, Bhaskar; Das Gupta, Shirshendu. Process for preparation of Ribociclib and its acid addition salts. WO 2018051280. (PCT Int. Appl. (2018))
产品链接: CAS No. 1211441-98-3 ››