网站主页>>>数据中心>>>工艺路线数据>>>Aprocitentan CAS# 1103522-45-7 N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧基]乙氧基]-4-嘧啶基]氨基磺酰胺
Aprocitentan CAS# 1103522-45-7 N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧基]乙氧基]-4-嘧啶基]氨基磺酰胺
Aprocitentan, also known as ACT-132577, is an endothelin receptor antagonist and an pharmacologically active metabolite of macitentan . Aprocitentan antagonized the specific binding of ET-1 on membranes of cells overexpressing ET(A) and ET(B) receptors and blunted ET-1-induced calcium mobilization in various natural cell lines, with inhibitory constants within the nanomolar range.
📌 参考资料/链接：
The Discovery of N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor AntagonistBy: Bolli, Martin H.; et alJournal of Medicinal Chemistry (2012), 55(17), 7849-7861
The Discovery of N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor AntagonistBy: Bolli, Martin H.; et alJournal of Medicinal Chemistry (2012), 55(17), 7849-7861
📄 详细内容
CAS No. 1103522-45-7 N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧基]乙氧基]-4-嘧啶基]氨基磺酰胺Aprocitentan synthetic routes
The Discovery of N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor AntagonistBy: Bolli, Martin H.; et alJournal of Medicinal Chemistry (2012), 55(17), 7849-7861
产品链接: CAS No. 1103522-45-7 ››
The Discovery of N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor AntagonistBy: Bolli, Martin H.; et alJournal of Medicinal Chemistry (2012), 55(17), 7849-7861
产品链接: CAS No. 1103522-45-7 ››