Aceclidine CAS# 827-61-2 乙酰克里定

Aceclidine is a cholinergic muscarinic receptor agonist primarily targeting ocular tissues. In preclinical receptor-binding assays, it showed high affinity for M₃ receptors (Ki ~30–50 nM) and moderate affinity for M₂ receptors, producing dose-dependent activation of smooth muscle contraction pathways. In isolated iris sphincter preparations, aceclidine induced marked miosis and increased aqueous humor outflow facility. In animal models of glaucoma, topical aceclidine reduced intraocular pressure by 25–40% within hours of dosing, with effects comparable to pilocarpine but longer lasting due to slower receptor dissociation. Toxicology studies in rodents showed good local tolerability with minimal systemic cholinergic effects.