Cilastatin CAS# 82009-34-5 西司他丁
Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependent beta-lactamase that usually confer antibiotic resistance to certain bacteria.
📌 参考资料/链接：
Reference: Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; Canning, Laura F.; Chen, Anna; Springer, James P.; Rogers, Edward F. Inhibition of the mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by Z-2-(acylamino)-3-substituted-propenoic acids. Journal of Medicinal Chemistry. Volume 30. Issue 6. Pages 1074-90. Journal. (1987).
Reference: Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; Canning, Laura F.; Chen, Anna; Springer, James P.; Rogers, Edward F. Inhibition of the mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by Z-2-(acylamino)-3-substituted-propenoic acids. Journal of Medicinal Chemistry. Volume 30. Issue 6. Pages 1074-90. Journal. (1987).
📄 详细内容
CAS No. 82009-34-5 西司他丁Cilastatin synthetic routes
Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; Canning, Laura F.; Chen, Anna; Springer, James P.; Rogers, Edward F. Inhibition of the mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by Z-2-(acylamino)-3-substituted-propenoic acids. Journal of Medicinal Chemistry. Volume 30. Issue 6. Pages 1074-90. Journal. (1987).
产品链接: CAS No. 82009-34-5 ››
Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; Canning, Laura F.; Chen, Anna; Springer, James P.; Rogers, Edward F. Inhibition of the mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by Z-2-(acylamino)-3-substituted-propenoic acids. Journal of Medicinal Chemistry. Volume 30. Issue 6. Pages 1074-90. Journal. (1987).
产品链接: CAS No. 82009-34-5 ››