Cabotegravir CAS# 1051375-10-0 卡替拉韦

Cabotegravir is a potent HIV-1 integrase strand transfer inhibitor (INSTI) that demonstrates strong in vitro activity, blocking viral DNA integration into host genomes at nanomolar concentrations with a high barrier to resistance. In cell-based assays, it maintains efficacy across diverse HIV-1 subtypes and shows synergistic effects when combined with nucleoside reverse transcriptase inhibitors. In vivo, cabotegravir exhibits long plasma half-life and favorable pharmacokinetics, enabling sustained antiretroviral activity with long-acting injectable formulations that provide durable viral suppression in preclinical and clinical models.