Niraparib CAS# 1038915-60-4 尼拉帕尼
Niraparib, also known as MK4827, is an orally active, potent and selective poly(ADP-Ribose) polymerase (PARP) inhibitor that radiosensitizes human lung and breast cancer cells. Niraparib inhibits PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM respectively. Niraparib is currently in Phase 3 clinical trials for ovarian cancer and BRCA+ breast cancer.
📌 参考资料/链接：
Reference: Jones, Philip; Ontoria Ontoria, Jesus Maria; Scarpelli, Rita; Schultz-Fademrecht, Carsten. Preparation of piperidinylphenylindazolylcarboxamide for use as poly(ADP-ribose)polymerase inhibitors. WO 2008084261. (Assignee Istituto Di Ricerche Di Biologia Molecolare P. Angeletti SpA, Italy)
Reference: Jones, Philip; Ontoria Ontoria, Jesus Maria; Scarpelli, Rita; Schultz-Fademrecht, Carsten. Preparation of piperidinylphenylindazolylcarboxamide for use as poly(ADP-ribose)polymerase inhibitors. WO 2008084261. (Assignee Istituto Di Ricerche Di Biologia Molecolare P. Angeletti SpA, Italy)
📄 详细内容
CAS No. 1038915-60-4 尼拉帕尼Niraparib synthetic routes
Jones, Philip; Ontoria Ontoria, Jesus Maria; Scarpelli, Rita; Schultz-Fademrecht, Carsten. Preparation of piperidinylphenylindazolylcarboxamide for use as poly(ADP-ribose)polymerase inhibitors. WO 2008084261. (Assignee Istituto Di Ricerche Di Biologia Molecolare P. Angeletti SpA, Italy)
产品链接: CAS No. 1038915-60-4 ››
Jones, Philip; Ontoria Ontoria, Jesus Maria; Scarpelli, Rita; Schultz-Fademrecht, Carsten. Preparation of piperidinylphenylindazolylcarboxamide for use as poly(ADP-ribose)polymerase inhibitors. WO 2008084261. (Assignee Istituto Di Ricerche Di Biologia Molecolare P. Angeletti SpA, Italy)
产品链接: CAS No. 1038915-60-4 ››