Telotristat ethyl CAS# 1033805-22-9 特罗司他乙酯
Telotristat ethyl, also known as LX 1032 or LX 1606, is an oral serotonin synthesis inhibitor or peripheral tryptophan hydroxylase (TPH) inhibitor . Telotristat etiprate has activity in controlling diarrhea associated with carcinoid syndrome. LX1606 acts by inhibiting the enzyme tryptophan hydoxylase (TPH) and reduces serotonin production both inside and outside the GI tract without affecting brain serotonin levels. TPH is the rate-limiting enzyme involved in serotonin biosynthesis and is present in metastatic carcinoid tumor cells.
📌 参考资料/链接：
Reference: Sands, Arthur Thomas. Preparation of multicyclic amino acid derivations as potent and selective THP1 inhibitors for treating metastatic bone disease. WO 2011100285. (Lexicon Pharmaceuticals, Inc., USA)
Reference: Sands, Arthur Thomas. Preparation of multicyclic amino acid derivations as potent and selective THP1 inhibitors for treating metastatic bone disease. WO 2011100285. (Lexicon Pharmaceuticals, Inc., USA)
📄 详细内容
CAS No. 1033805-22-9 特罗司他乙酯Telotristat ethyl synthetic routes
Sands, Arthur Thomas. Preparation of multicyclic amino acid derivations as potent and selective THP1 inhibitors for treating metastatic bone disease. WO 2011100285. (Lexicon Pharmaceuticals, Inc., USA)
产品链接: CAS No. 1033805-22-9 ››
Sands, Arthur Thomas. Preparation of multicyclic amino acid derivations as potent and selective THP1 inhibitors for treating metastatic bone disease. WO 2011100285. (Lexicon Pharmaceuticals, Inc., USA)
产品链接: CAS No. 1033805-22-9 ››