Rucaparib CAS# 283173-50-2 瑞卡帕布
Rucaparib is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis.
📌 参考资料/链接：
Reference: Belogi, Gianluca; Mazzoni, Andrea; Serra, Stefano; Novo, Barbara. Preparation of high-purity rucaparib via palladium-catalyzed regioselective coupling of a 4-alkoxycarbonyl-6-fluoroindole and an alkyl [(4-iodophenyl)methyl]methylcarbamate. WO 2019020508. (Olon S.p.A., Italy)
Reference: Belogi, Gianluca; Mazzoni, Andrea; Serra, Stefano; Novo, Barbara. Preparation of high-purity rucaparib via palladium-catalyzed regioselective coupling of a 4-alkoxycarbonyl-6-fluoroindole and an alkyl [(4-iodophenyl)methyl]methylcarbamate. WO 2019020508. (Olon S.p.A., Italy)
📄 详细内容
CAS No. 283173-50-2 瑞卡帕布Rucaparib synthetic routes
Belogi, Gianluca; Mazzoni, Andrea; Serra, Stefano; Novo, Barbara. Preparation of high-purity rucaparib via palladium-catalyzed regioselective coupling of a 4-alkoxycarbonyl-6-fluoroindole and an alkyl [(4-iodophenyl)methyl]methylcarbamate. WO 2019020508. (Olon S.p.A., Italy)
产品链接: CAS No. 283173-50-2 ››
Belogi, Gianluca; Mazzoni, Andrea; Serra, Stefano; Novo, Barbara. Preparation of high-purity rucaparib via palladium-catalyzed regioselective coupling of a 4-alkoxycarbonyl-6-fluoroindole and an alkyl [(4-iodophenyl)methyl]methylcarbamate. WO 2019020508. (Olon S.p.A., Italy)
产品链接: CAS No. 283173-50-2 ››