Ixabepilone CAS# 219989-84-1 伊沙匹隆
Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007.
📌 参考资料/链接：
Synthesis of epothilones, intermediates and analogs for use in treatment of cancers with multidrug resistant phenotype; Danishefsky, Samuel J.; Lee, Chul Bom; Chappell, Mark; Stachel, Shawn; Chou, Ting-chao; Assignee Sloan-Kettering Institute for Cancer Research, USA; 2001; Patent Information; Sep 07, 2001; WO 2001064650 A2
Synthesis of epothilones, intermediates and analogs for use in treatment of cancers with multidrug resistant phenotype; Danishefsky, Samuel J.; Lee, Chul Bom; Chappell, Mark; Stachel, Shawn; Chou, Ting-chao; Assignee Sloan-Kettering Institute for Cancer Research, USA; 2001; Patent Information; Sep 07, 2001; WO 2001064650 A2
📄 详细内容
CAS No. 219989-84-1 伊沙匹隆Ixabepilone synthetic routes
Synthesis of epothilones, intermediates and analogs for use in treatment of cancers with multidrug resistant phenotype; Danishefsky, Samuel J.; Lee, Chul Bom; Chappell, Mark; Stachel, Shawn; Chou, Ting-chao; Assignee Sloan-Kettering Institute for Cancer Research, USA; 2001; Patent Information; Sep 07, 2001; WO 2001064650 A2
产品链接: CAS No. 219989-84-1 ››
Synthesis of epothilones, intermediates and analogs for use in treatment of cancers with multidrug resistant phenotype; Danishefsky, Samuel J.; Lee, Chul Bom; Chappell, Mark; Stachel, Shawn; Chou, Ting-chao; Assignee Sloan-Kettering Institute for Cancer Research, USA; 2001; Patent Information; Sep 07, 2001; WO 2001064650 A2
产品链接: CAS No. 219989-84-1 ››