网站主页>>>数据中心>>>工艺路线数据>>>Bazedoxifene CAS# 198481-32-2 1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇
Bazedoxifene CAS# 198481-32-2 1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇
Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. In late 2013, Pfizer received approval for bazedoxifene as part of the combination drug DUAVEE in the prevention (not treatment) of postmenopausal osteoporosis. Bazedoxifene is an indole-based ER ligand that binds to both ERα (IC50 = 26 nM) and ERβ (IC50 = 99 nM).
📌 参考资料/链接：
Mylavarapu, Ravikumar; Kondaiah, G. C. M.; Reddy, L. Amaranth; Dubey, Manoj Kumar; Jasmine; Mukkanti, Kagga; Bandichhor, Rakeshwar. An improved synthesis of Bazedoxifene acetate. Chemistry & Biology Interface. Volume 5. Issue 2. Pages 137-150. Journal; Online Computer File. (2015).
Mylavarapu, Ravikumar; Kondaiah, G. C. M.; Reddy, L. Amaranth; Dubey, Manoj Kumar; Jasmine; Mukkanti, Kagga; Bandichhor, Rakeshwar. An improved synthesis of Bazedoxifene acetate. Chemistry & Biology Interface. Volume 5. Issue 2. Pages 137-150. Journal; Online Computer File. (2015).
📄 详细内容
CAS No. 198481-32-2 1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇Bazedoxifene synthetic routes
Mylavarapu, Ravikumar; Kondaiah, G. C. M.; Reddy, L. Amaranth; Dubey, Manoj Kumar; Jasmine; Mukkanti, Kagga; Bandichhor, Rakeshwar. An improved synthesis of Bazedoxifene acetate. Chemistry & Biology Interface. Volume 5. Issue 2. Pages 137-150. Journal; Online Computer File. (2015).
产品链接: CAS No. 198481-32-2 ››
Mylavarapu, Ravikumar; Kondaiah, G. C. M.; Reddy, L. Amaranth; Dubey, Manoj Kumar; Jasmine; Mukkanti, Kagga; Bandichhor, Rakeshwar. An improved synthesis of Bazedoxifene acetate. Chemistry & Biology Interface. Volume 5. Issue 2. Pages 137-150. Journal; Online Computer File. (2015).
产品链接: CAS No. 198481-32-2 ››