Caspofungin Acetate CAS# 179463-17-3 醋酸卡泊芬净
Caspofungin acetate is a lipopeptide antifungal drug. It is a member of a new class of antifungals termed the echinocandins. It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall. Caspofungin acetate for injection was originally approved by FDA in USA, and the EMEA in Europe, in 2001.
📌 参考资料/链接：
Leonard, William R., Jr.; Belyk, Kevin M.; Conlon, David A.; Bender, Dean R.; DiMichele, Lisa M.; Liu, Ji; Hughes, David L. Synthesis of the Antifungal β-1,3-Glucan Synthase Inhibitor CANCIDAS (Caspofungin Acetate) from Pneumocandin B0. Journal of Organic Chemistry. Process Research Department. Merck Research Laboratories. Rahway, USA 07065-0900. Volume 72. Issue 7. Pages 2335-2343. 2007
Leonard, William R., Jr.; Belyk, Kevin M.; Conlon, David A.; Bender, Dean R.; DiMichele, Lisa M.; Liu, Ji; Hughes, David L. Synthesis of the Antifungal β-1,3-Glucan Synthase Inhibitor CANCIDAS (Caspofungin Acetate) from Pneumocandin B0. Journal of Organic Chemistry. Process Research Department. Merck Research Laboratories. Rahway, USA 07065-0900. Volume 72. Issue 7. Pages 2335-2343. 2007
📄 详细内容
CAS No. 179463-17-3 醋酸卡泊芬净Caspofungin Acetate synthetic routes
Leonard, William R., Jr.; Belyk, Kevin M.; Conlon, David A.; Bender, Dean R.; DiMichele, Lisa M.; Liu, Ji; Hughes, David L. Synthesis of the Antifungal β-1,3-Glucan Synthase Inhibitor CANCIDAS (Caspofungin Acetate) from Pneumocandin B0. Journal of Organic Chemistry. Process Research Department. Merck Research Laboratories. Rahway, USA 07065-0900. Volume 72. Issue 7. Pages 2335-2343. 2007
产品链接: CAS No. 179463-17-3 ››
Leonard, William R., Jr.; Belyk, Kevin M.; Conlon, David A.; Bender, Dean R.; DiMichele, Lisa M.; Liu, Ji; Hughes, David L. Synthesis of the Antifungal β-1,3-Glucan Synthase Inhibitor CANCIDAS (Caspofungin Acetate) from Pneumocandin B0. Journal of Organic Chemistry. Process Research Department. Merck Research Laboratories. Rahway, USA 07065-0900. Volume 72. Issue 7. Pages 2335-2343. 2007
产品链接: CAS No. 179463-17-3 ››