Difelikefalin CAS# 1024828-77-0

Difelikefalin is a selective peripheral kappa opioid receptor agonist that exhibits high affinity and potency in vitro, where it reduces pro-inflammatory cytokine release and modulates nociceptive signaling without central nervous system penetration. In animal models, it demonstrates robust antinociceptive and antipruritic effects, with efficacy in reducing scratching behavior and inflammation-related responses. In vivo studies also show attenuation of chronic kidney disease–associated pruritus and inflammatory pain behaviors, supporting its therapeutic utility in peripheral pruritic and pain conditions.