Daclatasvir CAS# 1009119-64-5 达卡他韦
Daclatasvir (USAN), also known as BMS-790052 and EBP-883 (trade name Daklinza), is NS5A inhibitor and a drug for the treatment of hepatitis C (HCV). It is was developed by Bristol-Myers Squibb and was approved in Europe on 22 August 2014. Daclatasvir inhibits the HCV nonstructural protein NS5A. Recent research suggests that it targets two steps of the viral replication process, enabling rapid decline of HCV RNA. Daclatasvir has been tested in combination regimens with pegylated interferon and ribavirin, as well as with other direct-acting antiviral agents including asunaprevir and sofosbuvir.
📌 参考资料/链接：
Reference: Zong X, Cai J, Chen J, Wang P, Zhou G, Chen B, Li W, Ji M. Design and synthesis of imidazole N-H substituted amide prodrugs as inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3147-50. doi: 10.1016/j.bmcl.2015.06.006. Epub 2015 Jun 9. PubMed PMID: 26077493.
Reference: Zong X, Cai J, Chen J, Wang P, Zhou G, Chen B, Li W, Ji M. Design and synthesis of imidazole N-H substituted amide prodrugs as inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3147-50. doi: 10.1016/j.bmcl.2015.06.006. Epub 2015 Jun 9. PubMed PMID: 26077493.
📄 详细内容
CAS No. 1009119-64-5 达卡他韦Daclatasvir synthetic routes
Zong X, Cai J, Chen J, Wang P, Zhou G, Chen B, Li W, Ji M. Design and synthesis of imidazole N-H substituted amide prodrugs as inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3147-50. doi: 10.1016/j.bmcl.2015.06.006. Epub 2015 Jun 9. PubMed PMID: 26077493.
产品链接: CAS No. 1009119-64-5 ››
Zong X, Cai J, Chen J, Wang P, Zhou G, Chen B, Li W, Ji M. Design and synthesis of imidazole N-H substituted amide prodrugs as inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3147-50. doi: 10.1016/j.bmcl.2015.06.006. Epub 2015 Jun 9. PubMed PMID: 26077493.
产品链接: CAS No. 1009119-64-5 ››