Efinaconazole CAS# 164650-44-6 艾氟康唑
Efinaconazole is a triazole antifungal. It is approved for use in Canada and the USA as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nail). Efinaconazole acts as a 14α-demethylase inhibitor. Efinaconazole inhibits fungal lanosterol 14α-demethylase involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. Efinaconazole has been shown to be active against isolates of the following microorganisms, both in vitro and in clinical infections. Efinaconazole exhibits in vitro minimum inhibitory concentrations (MICs) of 0.06 μg/mL or less against most ( ≥ 90%) isolates of the following microorganisms: Trichophyton rubrum; Trichophyton mentagrophytes.
📌 参考资料/链接：
Tamura, Keiji; Kumagai, Naoya; Shibasaki, Masakatsu. An Enantioselective Synthesis of the Key Intermediate for Triazole Antifungal Agents; Application to the Catalytic Asymmetric Synthesis of Efinaconazole (Jublia). ournal of Organic Chemistry. Volume 79. Issue 7. Pages 3272-3278. Journal; Online Computer File. (2014).
Tamura, Keiji; Kumagai, Naoya; Shibasaki, Masakatsu. An Enantioselective Synthesis of the Key Intermediate for Triazole Antifungal Agents; Application to the Catalytic Asymmetric Synthesis of Efinaconazole (Jublia). ournal of Organic Chemistry. Volume 79. Issue 7. Pages 3272-3278. Journal; Online Computer File. (2014).
📄 详细内容
CAS No. 164650-44-6 艾氟康唑Efinaconazole synthetic routes
Tamura, Keiji; Kumagai, Naoya; Shibasaki, Masakatsu. An Enantioselective Synthesis of the Key Intermediate for Triazole Antifungal Agents; Application to the Catalytic Asymmetric Synthesis of Efinaconazole (Jublia). ournal of Organic Chemistry. Volume 79. Issue 7. Pages 3272-3278. Journal; Online Computer File. (2014).
产品链接: CAS No. 164650-44-6 ››
Tamura, Keiji; Kumagai, Naoya; Shibasaki, Masakatsu. An Enantioselective Synthesis of the Key Intermediate for Triazole Antifungal Agents; Application to the Catalytic Asymmetric Synthesis of Efinaconazole (Jublia). ournal of Organic Chemistry. Volume 79. Issue 7. Pages 3272-3278. Journal; Online Computer File. (2014).
产品链接: CAS No. 164650-44-6 ››