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Abarelix CAS# 183552-38-7 阿巴瑞克
Abarelix is a synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing horm...
Ma, Zhonggang; Guo, Dewen; Zeng, Dezhi; Wen, Yongjun. Method for synthesizing abarelix. Assignee Chengdu Shengnuo Biopharm Co., Ltd.. 2018.
Mobocertinib CAS# 1847461-43-1 莫博替尼/TAK-788
Mobocertinib, also known as TAK-788 and AP32788, is an investigational TKI with potent, selective preclinical activity against activating EGFR and HER2 mutations, including exon 20 insertions. TAK-7...
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing InhibitorsBy: Lategahn, Jonas ; et alJournal of Medicinal Chemistry (2022), 65(9), 6643-6655
Pretomanid CAS# 187235-37-6 (S)-6,7-二氢-2-硝基-6-[[4-(三氟甲氧基)苯基]甲氧基]-5H-咪唑并[2,1-B][1,3]恶嗪
Pretomanid, aslo known as PA-824, a bioreductive drug. PA-824 has potent in vitro activity against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant c...
Reference: Orita, Akihiro; Miwa, Kai; Uehara, Genta; Otera, Junzo. Integration of solventless reaction in a multi-step process: application to an efficient synthesis of PA-824. Advanced Synthesis & Catalysis. Volume 349. Issue 13. Pages 2136-2144. Journal. (2007).
Ensifentrine CAS# 1884461-72-6
Ensifentrine (RPL554) is a dual phosphodiesterase (PDE)3 and PDE4 inhibitor with both bronchodilatory and anti-inflammatory activities. In vitro, Ensifentrine inhibited PDE3A and PDE4B with IC₅₀ value...
Process for the preparation of N-(2-{(2E)-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl}ethyl)urea and intermediates thereofBy: AnonymousIP.com Journal (2025), 25(2A), 1-4
Olutasidenib CAS# 1887014-12-1 5-[1-(6-氯-2-氧-1H-喹啉-3-基)乙基胺]-1-甲基-6-氧硫苷-2-碳腈
Olutasidenib (FT-2102) is a potent, selective oral inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). In preclinical studies, it inhibited mutant IDH1 (R132H/C) enzyme activity with an IC50 of ~10...
This method was from Journal of Medicinal Chemistry (2020), 63(4), 1612-1623
6RK73 CAS# 1895050-66-4
6RK73 is a potent, selective, covalent, and irreversible inhibitor of ubiquitin C-terminal hydrolase L1 (UCHL1), an enzyme implicated in neurodegenerative diseases and cancer. In biochemical assays, 6...
1.1Reagents:Cesium carbonateSolvents:Acetonitrile;5 min, rt1.22 h, rt2.1Solvents:Tetrahydrofuran;5 min, 0 °C2.2Reagents:Diisopropylethylamine,Propylphosphonic anhydrideSolvents:Ethyl acetate;0 °C; 1 h, rt3.1Reagents:Hydrochloric acidSolvents:Dichloromethane,Ethyl acetate;0 °C; 4 h, rt4.1Reagents:Potassium carbonateSolvents:Dichloromethane;0 °C; 16 h, rt
Lazertinib CAS# 1903008-80-9 兰泽替尼
Lazertinib, also known as YH-25448 and GNS-1480, is an oral active, highly potent, mutant-selective and irreversible EGFR Tyrosine-kinase inhibitors (TKIs) targets both the T790M mutation and activati...
Patent#: WO2019022485
Danicopan CAS# 1903768-17-1
Danicopan (ACH-4471) is a selective small-molecule inhibitor of complement factor D, targeting the alternative pathway of complement activation. In vitro, danicopan potently inhibited human factor D e...
First-in-Class Clinically Investigated Oral Factor D Inhibitors for the Treatment of Complement-Mediated DiseasesBy: Gadhachanda, Venkat R.; et alPharmaceutical Research (2025), 42(7), 1119-1131
Sebetralstat CAS# 1933514-13-6
Sebetralstat is a highly potent and selective oral small-molecule inhibitor of plasma kallikrein (PKa), with a Ki of ~3.0 nM and an isolated human PKa IC₅₀ of ~6.0 nM. In human whole plasma stimulated...
Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary AngioedemaBy: Davie, Rebecca L.; et alJournal of Medicinal Chemistry (2022), 65(20), 13629-13644
Clascoterone CAS# 19608-29-8 21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮
Lipase-catalyzed preparation of corticosteroid 17α-esters endowed with antiandrogenic activityBy: Ferraboschi, Patrizia; et alTetrahedron Letters (2008), 49(31), 4610-4612
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